Mapping Resolution in Single and Multiple Porcine F2 Populations using Genome Sequence Marker Panels
نویسندگان
چکیده
Porcine F2 crosses derived from distantly or closely ‘related’ founder breeds have frequently been used for QTL mapping. Increasing marker density up to a maximum level can be done by re-sequencing and imputation techniques. This study investigated by means of simulations the mapping resolution and LD structure around causal genes of several F2 crosses with maximum marker density. It is shown that the mapping resolution is high (low) in F2 cross from closely (distantly) ‘related’ founder breeds. Poling data from several crosses improves mapping resolution substantially. In addition, it is shown that for causal genes segregating in a particular founder breed, the number of markers being in high LD is smaller in pooled F2 crosses than in the founder breed itself. This high mapping resolution makes pooled F2 crosses with maximum marker density suitable for identification of segregating causal genes.
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